Oncological diseases are one of the leading health problems both in the world and in Kazakhstan, second only to cardiovascular diseases.Hepatocellular carcinoma occupies the 8th place in the structure of oncopathologies, has an unfavorable CD Wire Harness prognosis and an unfavorable course.According to the WHO, more than 1.3 million people die eac
Abstract Background Although sub-Saharan Africa (SSA) is rapidly urbanizing, the terms used to classify urban ecotypes are poorly defined in the context of malaria epidemiology.Lack of clear definitions may cause misclassification error, which likely decreases the accuracy of continent-wide estimates of malaria burden, limits the generalizability o
The study involves two groups of seals: 1) seals of the individuals who can be identified as the Alexiad personages: Alexios Komnenos as sebastos and megas domestikos (the first group) and emperor (the second one); his brother Adrianos Komnenos as protosebastos (the first group), protosebastos and megas domestikos of all the West (the second one) a
A conserved AAA+ ATPase, called Cdc48 in yeast and p97 or VCP in metazoans, plays an essential role in many cellular processes by segregating polyubiquitinated proteins from complexes or membranes.For example, in endoplasmic reticulum (ER)-associated protein degradation (ERAD), Cdc48/p97 pulls polyubiquitinated, misfolded proteins out of the ER and